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KMID : 1103720110640020179
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Journal of the Korean Society of Radiology
2011 Volume.64 No. 2 p.179 ~ p.184
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Value of Diffusion Tensor Imaging of Prostate Cancer: Comparison with Systemic Prostate Biopsy
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Yoon Seong-Kuk
Kim Dong-Won
Ha Dong-Ho
Kwon Hee-Jin
Kang Myong-Jin
Choi Sun-Seob
Nam Kyeong-Jin
Kim Jung-Il
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Abstract
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Purpose: This study was performed to evaluate the usefulness of diffusion tensor imaging (DTI) and to correlate systemic twelve biopsy in prostate cancer.
Materials and Methods: Thirty-one patients with suspected prostate cancer underwent MR imaging. DTI was performed prior to a prostate biopsy. We prospectively calculated the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) value in each corresponding biopsy site.
Results: Twenty-three of 31 patients had histopathologically proven adenocarcinoma. Among the 276 biopsy cores of 23 patients with prostate cancer, 109 cores showed positive results (39%). The ADC and FA value of positive cores were 1.31 ± 0.34×10-3 mm2/s and 0.68 ± 0.07, and those of the negative cores were 1.74 ± 0.45×10-3 mm2/s and 0.54 ± 0.09, respectively. Eight patients without carcinoma showed an ADC value of 1.83 ± 0.26×10-3 mm2/s and an FA value of 0.47 ± 0.07. The ADC and FA value of positive cores were significantly lower and higher than those of negative cores and cancer-free patients, respectively (p < 0.05).
Conslusion: The ADC and FA values using DTI may provide useful diagnostic information in the differentiation of cancerous tissues, although there is overlap in some cases.
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KEYWORD
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Prostate, Prostate Neoplasms, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging
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